GenerativeX

AI Annotations Built

For Pharma Documentation

Highlight protocol gaps, SAP inconsistencies, and labelling risks

where reviewers already work - directly inside the PDF viewer.

Protocols / SAP & CSR / SOP / Labeling / CAPA

Pharma PDF annotation agent

Interactive demos across pharma workflows

Switch between protocol QA, SOP review, labelling alignment, and PV signal triage to see annotation-ready output in action.

Sample clinical protocol

Upload your own protocol, SAP, or CSR to mirror this workflow.

Or preview an annotated output first

Clear use cases for every pharma function

Map the agent to your SOPs in hours. Each use case below ships with ready-made prompts, annotation styles, and compliance guardrails.

Clinical development / Medical writing

Challenge

Protocol, SAP, and CSR alignment checks consume days and issues are still found during review board.

How the agent helps

Cross-links evaluation criteria, visit schedules, and analysis populations, highlighting mismatches and jumping reviewers to the exact paragraph.

Example annotation

[High] SAP section 3.2 analysis cohort does not match Protocol section 5.1. Review linked paragraphs.

Clinical operations (audit response)

Challenge

Audit findings live in long email chains and assembling evidence packs is manual.

How the agent helps

Keep observation, corrective plan, and supporting documents inside one PDF comment thread so the full story is inspection ready.

Example annotation

Audit-012 thread: Observation -> Corrective action -> Evidence attachment captured in PDF.

Nonclinical / CMC

Challenge

Unit conversions, release specs, and lot metadata drift across large submission packages.

How the agent helps

Extract numeric fields, compare them to master specifications, and highlight deviations directly in stability reports and batch records.

Example annotation

Lot 24B torque spec differs from last qualified lot 23Q by +12%.

IRB / IEC submissions

Challenge

Patient-facing materials mix complex terminology with missing required statements.

How the agent helps

Classifies hard-to-read sentences, suggests plainer alternatives, and flags absent consent language so committees sign off faster.

Example annotation

[Medium] Replace jargon: "Patients will visit four times" suggested for section 2.1.

Quality assurance / GxP

Challenge

Revision projects miss critical warnings, torque values, or rationales buried in SOP text.

How the agent helps

Pre-highlights critical instructions, captures reason-for-change comments, and keeps revision history auditable in the PDF.

Example annotation

[Alert] SOP-17 section 4.3 torque value removed compared to prior revision.

Manufacturing and QC

Challenge

Batch record templates vary by site and CAPA follow-up stalls on missing entries.

How the agent helps

Detects mandatory fields left blank, tags them with "Evidence required" comments, and tracks completion status across batches.

Example annotation

Tag: Evidence required -> CAPA-552 deviation summary not documented.

Regulatory affairs (labelling / eCTD)

Challenge

Maintaining consistency between SmPC, PI, IFU, and submission modules is tedious and error prone.

How the agent helps

Diffs labelling language, highlights prohibited terms, and links annotations to source evidence for faster justification.

Example annotation

[High] Term "cure" detected in PI section 4.1. Refer to labelling policy LP-203.

Pharmacovigilance (PBRER / PSUR / RMP)

Challenge

Safety reports ship with missing sections or inconsistent MedDRA coding.

How the agent helps

Checks structure against required templates, suggests code harmonisation, and flags sections still marked incomplete.

Example annotation

Section 4.8 flagged: MedDRA preferred term for rash inconsistent with case series appendix.

Commercial review / Medical affairs

Challenge

Promo materials require rapid turnaround but claims and references are hard to verify at scale.

How the agent helps

Highlights comparative or superlative claims, prompts for evidence, and tags missing references before approval meetings.

Example annotation

To-do: Provide Phase III ORR reference for slide 12 claim before sign-off.

Legal, procurement, and security

Challenge

CRO MSAs and DPAs hide key differences in IP ownership, subcontracting, or liability language.

How the agent helps

Color-codes clauses by risk, extracts limitation language, and notifies reviewers when terms break policy thresholds.

Example annotation

Risk: Indemnity cap in Exhibit B exceeds template baseline by 50%.

Built around pharma documentation bottlenecks

The agent reads every page, cross-references master data, and posts highlights straight onto the PDF, so clinical, quality, and regulatory teams stay aligned.

Clinical R&D

Protocol / SAP / CSR integrity

Detect mismatches in endpoints, visit schedules, and analysis populations before QC flags them.

[High] SAP 3.2 analysis cohort != Protocol 5.1. Jump to paragraph

Clinical Ops

Audit readiness threads

Respond to audit findings in a single annotation thread - from observation to corrective evidence.

Audit-001 -> Investigator email + CAPA plan linked in thread

Nonclinical / CMC

Unit & lot normalization

Surface inconsistent units, specs, and lot metadata with auto-highlighted diffs against prior versions.

Lot 24B torque spec deviates from 23Q baseline

IRB / IEC

Readability & required clauses

Flag jargon and missing consent statements; insert ready-to-use patient friendly language inside the PDF.

[Medium] Suggest: "The study requires four clinic visits."

Quality / GxP

Critical instruction safeguard

Highlight torque values, warnings, and revision rationales so SOP updates never miss compliance-critical text.

[Alert] SOP-17 section 4.3 torque value removed in latest draft

Manufacturing & QC

Batch record completeness

Auto-tag blank mandatory fields and add "Evidence Required" annotations to speed CAPA close-out.

Tag: Evidence Required -> CAPA-552 missing deviation summary

Regulatory Affairs

Labeling & eCTD cross-check

Compare SmPC / PI language, spot banned terms, and link back to supporting references via comment threads.

[High] "Cure" phrasing conflicts with JP label guidance

Pharmacovigilance

PSUR / RMP governance

Confirm required sections, suggest MedDRA code harmonization, and mark unaddressed safety updates.

Section 4.8 missing MedDRA PT for rash events

Commercial / MedAffairs

Promo asset scrutiny

Highlight over-claims, comparative statements, and request evidence before approval workflows move forward.

To-do -> Provide Phase III reference for ORR claim

Legal & Procurement

Contract risk surfacing

Color-code clauses around IP ownership, indemnity, and subcontractors to help legal triage vendor agreements.

Risk: Indemnity cap exceeds master template

How teams ship audit-ready PDFs in hours

Purpose-built prompts, annotation templates, and export options map to the documents you already manage today.

1. Upload with context

Drop your protocol, SOP, or labeling PDF and add quick instructions like target endpoints, banned phrases, or CAPA IDs.

2. Let the agent annotate

The agent cross-checks related documents, highlights mismatches, and opens comment threads your SMEs can edit in place.

3. Export and archive

Download annotated PDFs, export audit trails, or push threads to your QMS so every action is traceable.

Pricing Plans

Choose the plan that fits your needs. Start for free and scale as you grow.

Free

For individuals and small projects getting started.

$0

/ user / month

Free Trial
  • Up to 10 file uploads
  • Multi-file analysis
  • WebSearch Integration
  • FileSystem Integration
  • Background & Chat Ops
  • Self-hosted Cloud Deployment
  • Customer Support

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Pro

For professionals and teams requiring advanced features.

$5

/ user / month

Free Trial
  • Unlimited file uploads
  • Multi-file analysis
  • WebSearch Integration
  • FileSystem Integration
  • Background & Chat Ops
  • Self-hosted Cloud Deployment
  • Email Support

Enterprise

For large organizations with custom needs and security requirements.

Ask

Contact Sales
  • Unlimited file uploads
  • Multi-file analysis
  • WebSearch Integration
  • FileSystem Integration
  • Background & Chat Ops
  • Self-hosted Cloud Deployment
  • Dedicated Support & SLA

Ready to pilot with your regulated PDFs?

Share a work email and we will spin up a secure sandbox with pharma-ready prompts, annotation templates, and onboarding for your team.